Rationale. Lower limb amputations due to combat trauma, primarily mine blast wounds, represent one of the most severe categories of injuries, requiring the development and implementation of comprehensive, multi-stage rehabilitation programs. Objective. To analyze the patent landscape and current scientific and medical approaches to the rehabilitation of patients with lower limb amputations due to combat trauma to identify the most promising areas and justify the development of a full-cycle rehabilitation model. Materials and Methods. An analysis of patent documentation (FIPS, EAPO, WIPO, USPTO, Google Patents, lens.org databases) and scientific and medical literature (PubMed, eLibrary, Cyberleninka) for the period 2000-2026 was conducted. The study focused on methods and tools used at all stages of rehabilitation: stump preparation for prosthetics, prosthetics, non-pharmacological (physical) methods, and psychopharmacological correction. Results. The analysis identified three key areas of patenting and scientific development. The first area is technologies aimed at preparing the stump for prosthetics and improving prosthetic components. Developments have been identified in the areas of surgical preparation of the bone stump, customized socket manufacturing using 3D printing and pressure sensors, and the creation of highly functional prosthetic modules, including microprocessor-controlled knee joints and foot prostheses with improved biomechanics. The second area is represented by non-drug technologies, including the use of virtual reality (VR) with biofeedback (BFB) to restore movement patterns and relieve phantom pain, mirror therapy, brain-computer interfaces, and a wide range of simulators and devices for training support and maneuverability. The third area encompasses methods for relieving post-amputation pain syndrome (PAP), where, in addition to traditional pharmacotherapy, multimodal approaches using botulinum therapy, neuromodulation, and psychotherapeutic methods are being actively developed. A comparative analysis of international and Russian clinical guidelines was also conducted, identifying common principles and distinctive features of the approaches. Conclusion. The analysis shows that rehabilitation of patients with combat-related lower limb amputations is moving toward personalized and high-tech solutions. The most promising areas include: the development of innovative stump preparation methods with objective load monitoring, the creation of intelligent prostheses with adaptive control, the implementation of immersive technologies (VR/AR) and brain-computer interfaces for neurorehabilitation, and the standardization of full-cycle rehabilitation protocols.